Ironwood Pharmaceuticals has patented a novel process for preparing compounds that stimulate soluble guanylate cyclase (sGC). The process allows for large-scale production of stable 3-(2-pyrimidinyl)pyrazoles with high purity and yields, using easily scalable reaction conditions. The patent also covers novel intermediates for compound preparation. GlobalData’s report on Ironwood Pharmaceuticals gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Ironwood Pharmaceuticals, Peptide pharmacophores was a key innovation area identified from patents. Ironwood Pharmaceuticals's grant share as of January 2024 was 28%. Grant share is based on the ratio of number of grants to total number of patents.
A recently granted patent (Publication Number: US11834444B2) discloses a process for preparing various compounds of Formula III, including compounds of Formula V and Formula VI. The process involves treating bromo intermediate 15 in certain instances. Additionally, the patent covers the preparation of specific compounds such as Compound I, Compound IA, and Compound IB, each with their unique characteristics and methods of synthesis.
Furthermore, the patent details specific structural requirements for the compounds, such as the nature of the heteroaryl ring (5-membered or 6-membered) and the possible substitutions on the phenyl group. For instance, R1 can be a 5-membered heteroaryl ring containing up to three heteroatoms, isoxazolyl, or 3-isoxazolyl, while R2 can be phenyl with various substitution patterns, including 2-fluorophenyl. These detailed structural guidelines aim to ensure the reproducibility and specificity of the synthesis process for the compounds outlined in the patent.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
