KER-012 is under clinical development by Keros Therapeutics and currently in Phase II for Diastolic Heart Failure (HFpEF). According to GlobalData, Phase II drugs for Diastolic Heart Failure (HFpEF) does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the KER-012 LoA Report. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
KER-012 is under development for the treatment of osteoporosis, osteogenesis imperfecta, pulmonary arterial hypertension and chronic heart failure with preserved ejection fraction and with reduced ejection fraction. The therapeutic candidate comprises of modified ligand-binding domain of the activin receptor type IIB (ActRIIB) is fused to Fc domain of the human antibody. It acts by targeting activin A and B. It is administered through subcutaneous route.
Keros Therapeutics overview
Keros Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of novel treatments for hematological and musculoskeletal disorders. The company’s product pipeline includes KER-050 for the treatment of low blood cell counts, cytopenias, including anemia and thrombocytopenia for patients with myelodysplastic syndrome (MDS) and myelofibrosis (MF); KER-047 for treating functional iron deficiency (FID) anemia in MDS and myelofibrosis (MF). Its pipeline also includes KER-012 to treat pulmonary arterial hypertension and chronic heart failure with preserved ejection fraction; and KER-065 to treat duchenne muscular dystrophy. The company is developing other drug programs which are at pre-clinical stage in areas of musculoskeletal disorders. Keros Therapeutics is headquartered in Lexington, Massachusetts, the US.
For a complete picture of KER-012’s drug-specific PTSR and LoA scores, buy the report here.