KER-012 is a fusion protein commercialized by Keros Therapeutics, with a leading Phase II program in Systolic Heart Failure. According to Globaldata, it is involved in 3 clinical trials, of which 1 was completed, and 2 are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of KER-012’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

Smarter leaders trust GlobalData

The revenue for KER-012 is expected to reach an annual total of $84 mn by 2039 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

KER-012 Overview

KER-012 is under development for the treatment of osteoporosis, osteogenesis imperfecta, pulmonary arterial hypertension and chronic heart failure with preserved ejection fraction and with reduced ejection fraction. The therapeutic candidate comprises of modified ligand-binding domain of the activin receptor type IIB (ActRIIB) is fused to Fc domain of the human antibody. It acts by targeting activin A and B. It is administered through subcutaneous route.

Keros Therapeutics Overview

Keros Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of novel treatments for hematological and musculoskeletal disorders. The company’s product pipeline includes KER-050 for the treatment of low blood cell counts, cytopenias, including anemia and thrombocytopenia for patients with myelodysplastic syndrome (MDS) and myelofibrosis (MF); KER-047 for treating functional iron deficiency (FID) anemia in MDS and myelofibrosis (MF). Its pipeline also includes KER-012 to treat pulmonary arterial hypertension and chronic heart failure with preserved ejection fraction; and KER-065 to treat duchenne muscular dystrophy. The company is developing other drug programs which are at pre-clinical stage in areas of musculoskeletal disorders. Keros Therapeutics is headquartered in Lexington, Massachusetts, the US.

The operating loss of the company was US$114.8 million in FY2022, compared to an operating loss of US$56.4 million in FY2021. The net loss of the company was US$104.7 million in FY2022, compared to a net loss of US$58.7 million in FY2021.

For a complete picture of KER-012’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 7 February 2024

Premium Insights


The gold standard of business intelligence.

Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.