Ligufalimab is a monoclonal antibody commercialized by Akeso, with a leading Phase II program in Esophageal Squamous Cell Carcinoma (ESCC). According to Globaldata, it is involved in 12 clinical trials, of which 2 were completed, 9 are ongoing, and 1 is planned. GlobalData uses proprietary data and analytics to provide a complete picture of Ligufalimab’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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Data Insights Net Present Value Model: Akeso Inc's Ligufalimab

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The revenue for Ligufalimab is expected to reach an annual total of $32 mn by 2036 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Ligufalimab Overview

Ligufalimab is under development for the treatment of relapsed/refractory acute myeloid leukemia, myelodysplastic syndrome (MDS), relapsed or refractory advanced or metastatic solid tumors and non-Hodgkin lymphoma (NHL), head and neck cancer and gastrointestinal tumor, epithelial ovarian cancer, transitional cell cancer (urothelial cell cancer), metastatic hormone refractory (castration resistant, androgen-independent) prostate cancer, head and neck cancer squamous cell carcinoma, primary peritoneal cancer, fallopian tube cancer, hepatocellular carcinoma, cervical cancer, metastatic biliary tract cancer, intrahepatic or extrahepatic cholangiocarcinoma, gallbladder cancer, pancreatic ducts adenocarcinoma, gastric cancer, adenocarcinoma of the gastroesophageal junction, esophageal squamous cell carcinoma, urothelial carcinoma, colorectal adenocarcinoma, non-small cell lung cancer, metastatic colorectal cancer, small cell lung cancer, sarcoma, triple-negative breast cancer and oral cavity cancer, oropharyngeal cancer, hypopharyngeal cancer, laryngeal cancer and recurrent or metastatic head And neck cancer squamous cell carcinoma. The drug candidate is a monoclonal antibody acts by targeting leukocyte surface antigen CD47. It is administered through intravenous drip route.

Akeso Overview

Akeso is a clinical-stage biopharmaceutical company that focuses on in-house discovery and development of mono and bi-specific antibody drugs. The company’s product pipeline includes Ak101 and Ak111 targeting plaque psoriasis; Ak102 for the treatment of hypercholesterolemia; Ak104 against cancer; Ak105 for treating anlotinib; and Ak112 against solid tumors. It also offers kangfang integrated development platform (ACE Platform) which covers all drug research and development, including target verification, antibody discovery and also development functions. The company works in partnership with MERCK & CO Inc, Dawnrays Pharmaceutical Holdings Ltd, Sino Biopharmaceutical Ltd and China Biopharma. Akeso is headquartered in Zhongshan, Guangdong, China
The company reported revenues of (Renminbi) CNY4,526.3 million for the fiscal year ended December 2023 (FY2023), compared to a revenue of CNY837.7 million in FY2022. The operating profit of the company was CNY2,029.5 million in FY2023, compared to an operating loss of CNY1,378.9 million in FY2022. The net profit of the company was CNY2,028.3 million in FY2023, compared to a net loss of CNY1,168.4 million in FY2022.

For a complete picture of Ligufalimab’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.