GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Acute Heart Failure overview

Acute heart failure (AHF) is a critical medical condition characterized by a sudden onset or rapid worsening of symptoms related to the heart’s inability to pump blood effectively. This leads to insufficient oxygen delivery to tissues and organs. AHF can manifest as either new-onset heart failure or exacerbation of chronic heart failure. Common symptoms include shortness of breath, fatigue, and fluid retention, often resulting in pulmonary congestion and peripheral edema. Various factors such as coronary artery disease, hypertension, or infections can precipitate AHF. Prompt diagnosis, often through clinical evaluation and imaging, guides immediate interventions, including medications and, in severe cases, mechanical support or surgical interventions to optimize cardiac function and improve outcomes.

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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.