Open-Angle Glaucoma is an indication for drug development with over 50 pipeline drugs currently active. According to GlobalData, preregistered drugs for Open-Angle Glaucoma have a 90.91% likelihood of approval (LoA) indication benchmark. GlobalData’s report assesses how phase transition success rate (PTSR) and likelihood of approval (LoA) scores for pipeline drugs in Open-Angle Glaucoma compared to historical benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Open-Angle Glaucoma overview

Open-angle glaucoma is a chronic eye condition characterized by increased intraocular pressure (IOP) that damages the optic nerve, leading to gradual and irreversible vision loss. It is the most common form of glaucoma and develops slowly over time, often without noticeable symptoms in the early stages. In open-angle glaucoma, the drainage system within the eye becomes less efficient over time, leading to a buildup of aqueous humor (fluid) and an increase in intraocular pressure. Elevated pressure damages the optic nerve, which transmits visual information to the brain, causing gradual vision loss. Risk factors include age (more common in individuals over 40), family history of glaucoma, high IOP, certain medical conditions (such as diabetes and hypertension), and certain ethnicities (African Americans have a higher risk). Early-stage, open-angle glaucoma often presents without noticeable symptoms or vision changes. As the condition progresses, peripheral vision loss (usually unnoticed at first) gradually advances to tunnel vision and, if untreated, can lead to complete blindness.

For a complete picture of PTSR and LoA scores for drugs in Open-Angle Glaucoma, buy the report here.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. 

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.