GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Thrombocythemia Myelofibrosis overview

Essential thrombocythemia (ET) is a rare blood cancer that causes the body to produce too many platelets. Thrombocythemia is most often caused by gene mutations of JAK2, CALR, and MPL genes that affect formation of platelets from bone marrow. Exposure to benzene may increase the risk of developing myeloproliferative neoplasms. Signs and symptoms may include: Feeling tired, weak or short of breath, usually because of anemia, Pain or fullness below your ribs on the left side, due to an enlarged spleen, easy bruising and bleeding, night sweats, fever and bone pain. Pacritinib is an oral JAK inhibitor is the first treatment for adults with myelofibrosis and severe thrombocytopenia.

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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.