Linerixibat is a small molecule commercialized by GSK, with a leading Phase III program in Pruritus. According to Globaldata, it is involved in 15 clinical trials, of which 12 were completed, and 3 are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of Linerixibat’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for Linerixibat is expected to reach an annual total of $37 mn by 2033 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Linerixibat is under development for the treatment of cholestatic pruritus in patients with primary biliary cirrhosis (PBC). The drug candidate is administered as an orally as a tablet or as a solution. GSK-2330672 is a small molecule, which acts by targeting an ileal bile acid transporter. It is a new molecular entity. It was also under development for the treatment of type 2 diabetes.
GSK is a healthcare company that focuses on developing, manufacturing and commercializing pharmaceuticals, vaccines and consumer healthcare products. It offers drugs for the treatment of diseases such as HIV, respiratory, cancer, immuno-inflammation, anti-viral, central nervous system (CNS), metabolic, cardiovascular and urogenital, anti-bacterials, dermatology and rare diseases. The company also offers over-the-counter (OTC) products for pain relief, oral health, nutrition, skin health and gastro-intestinal diseases. GSK’s vaccine portfolio covers various diseases including hepatitis, diphtheria, tetanus, whooping cough, rotavirus and HPV infections, measles and bacterial meningitis, among others. The company sells its products through wholesalers, pharmacies, hospitals, physicians and other groups worldwide. GSK is headquartered in Brentford, Middlesex, the UK.
The company reported revenues of (British Pounds) GBP29,324 million for the fiscal year ended December 2022 (FY2022), an increase of 18.7% over FY2021. The operating profit of the company was GBP6,433 million in FY2022, compared to an operating profit of GBP4,321 million in FY2021. The net profit of the company was GBP14,751 million in FY2022, compared to a net profit of GBP3,874 million in FY2021.
For a complete picture of Linerixibat’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.