MRT-2359 is a small molecule commercialized by Monte Rosa Therapeutics, with a leading Phase II program in Non-Small Cell Lung Cancer. According to Globaldata, it is involved in 1 clinical trial, which is ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of MRT-2359’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

The revenue for MRT-2359 is expected to reach an annual total of $43 mn by 2035 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

MRT-2359 Overview

MRT-2359 is under development for the treatment of solid tumors including small-cell lung cancer, non-small cell lung cancer, diffuse large B-cell lymphoma, triple-negative breast cancer (TNBC), multiple myeloma (Kahler disease), neuroendocrine cancer and ovarian cancer. The drug candidate is a molecular glue degrader selectively targeting GSPT1. It is administered orally and is being developed based on Quantitative and Engineered Elimination of Neosubstrates (QuEEN) platform.

Monte Rosa Therapeutics Overview

Monte Rosa Therapeutics is a biotechnology company developing small molecules to degrade disease-related proteins. The company is headquartered in Boston, Massachusetts, the US.

The operating loss of the company was US$72.9 million in FY2021, compared to an operating loss of US$28 million in FY2020. The net loss of the company was US$74 million in FY2021, compared to a net loss of US$35.9 million in FY2020.

For a complete picture of MRT-2359’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.