NC-410 is under clinical development by NextCure and currently in Phase II for Solid Tumor. According to GlobalData, Phase II drugs for Solid Tumor have a 10% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how NC-410’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

NC-410 overview

NC-410 is under development for the treatment of metastatic solid tumors, ovarian, colorectal, cervical, pancreatic, gastric cancers, head and neck squamous cell carcinoma, endometrial cancer, prostate cancer, gastroesophageal junctions carcinomas, esophageal cancer and non- small cell lung cancer. The drug candidate is developed based on functional, integrated, nextCure discovery in immuno oncology (FIND-IO) technology. The drug candidate acts by targeting leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) and leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2). It is administered through intravenous route.

It was also under development for the treatment of blood tumors.

NextCure overview

NextCure is biopharmaceutical company that develops immune medicines to treat cancer and other immune-related diseases. The company’s product portfolio includes FIND-IO technology platform to discover and understand targets and structural components of immune cells and their functional impact in order to develop immunomedicines. Its pipeline products include protein drugs such as NC762, NC525 and NC410 are expressed on highly immunosuppressive cells and tumor cells. It is also pursuing partnering opportunities with pharmaceutical and biotechnology companies to discover and develop biologic-based therapeutics for the treatment of cancer, autoimmune, neurological disorders and expanding to a variety of therapeutic areas. NextCure is headquartered in Beltsville, Maryland, the US.

For a complete picture of NC-410’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.