Nedosiran sodium is under clinical development by Novo Nordisk and currently in Phase I for Primary Hyperoxaluria. According to GlobalData, Phase I drugs for Primary Hyperoxaluria have a 75% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how Nedosiran sodium’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Nedosiran sodium overview

Nedosiran Sodium (Rivfloza) is a RNA interference (RNAi) therapeutic. It is formulated as solution for subcutaneous route of administration. Rivfloza is indicated to lower urinary oxalate levels in children 9 years of age and older and adults with primary hyperoxaluria type 1 (PH1) and relatively preserved kidney function.

Nedosiran is under development for the treatment of primary hyperoxaluria type I, type II, type III, alpha-1 antitrypsin deficiency. The drug candidate is administered through subcutaneous route. It is a siRNA which targets lactate dehydrogenase enzyme A (LDHA). It is developed based on DsiRNA-EX-conjugate (GalXc) delivery system that enable subcutaneous delivery of RNAi therapies to hepatocytes in the liver.

It was also under development for rare blood disorders.

Novo Nordisk overview

Novo Nordisk, a subsidiary of Novo Holdings AS, is a healthcare company with focus on discovering, developing, and manufacturing biological medicines. It focuses on advancing drugs for the treatment of diabetes and other serious and chronic conditions including haemophilia, human growth hormone (HGH) disorders, rare blood and rare endocrine diseases and obesity. The company’s portfolio includes pre-filled delivery systems for insulin; glucagon hypokit; cartridge; needles; vials; insulin; estradiol for hormone replacement; recombinant drugs for haemophilia; glucagon; and oral antidiabetic agents. The company markets its products through subsidiaries in North America, Europe, Asia, Latin America, Africa, the Middle East and Australia. Novo Nordisk is headquartered in Bagsvaerd, Denmark.

For a complete picture of Nedosiran sodium’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.