Nelipepimut-S is under clinical development by SELLAS Life Sciences Group and currently in Phase II for Human Epidermal Growth Factor Receptor 2 Positive Breast Cancer (HER2+ Breast Cancer). According to GlobalData, Phase II drugs for Human Epidermal Growth Factor Receptor 2 Positive Breast Cancer (HER2+ Breast Cancer) have a 45% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Nelipepimut-S’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Nelipepimut-S overview
Nelipepimut-s (NeuVax) is under development for the prevention and treatment of gastric cancer, HER2 low expressing breast cancer, HER2+ breast cancer, triple negative breast cancer, and ductal carcinoma in situ. The drug candidate is administered as intradermal injection. It consists of the E75 peptide derived from human epidermal growth factor receptor 2 (HER2) combined with the immune adjuvant granulocyte macrophage colony stimulating factor (GM-CSF). The vaccine candidate was also under development for the treatment of prostate, ovarian and, pancreatic cancer.
SELLAS Life Sciences Group overview
SELLAS Life Sciences Group (SELLAS) is a clinical biopharmaceutical company. Its products include GFH009, a highly selective small molecule cyclin-dependent kinase 9 (CDK9) inhibitor and galinpepimut-S. Galinpepimut-S (GPS), a cancer immunotherapeutic drug that targets Wilms tumour 1, is in Phase 3 clinical studies for the treatment of acute myeloid leukaemia and in Phase 1/2 clinical trials for the treatment of ovarian cancer. The company collaborates with Memorial Sloan Kettering Cancer Center (MSKCC), National Cancer Institute (NCI) and The University of Texas M.D. Anderson Cancer Center (MDACC) for conducting clinical trials targeting multiple cancer indications. SELLAS is headquartered in New York City, New York, the US.
For a complete picture of Nelipepimut-S’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
