NUC-7738 is under clinical development by NuCana and currently in Phase II for Chordoma. According to GlobalData, Phase II drugs for Chordoma does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the NUC-7738 LoA Report. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

NUC-7738 overview

NUC-7738 is under development for the treatment of solid tumors including metastatic cutaneous melanoma, metastatic lung adenocarcinoma, metastatic clival chordoma, B-cell non-Hodgkin lymphomas (NHL), Hodgkin's lymphoma, T-cell lymphomas, lymphoma and kidney cancer. It is administered through intravenous route. The drug candidate is a ProTide transformation of 3’-deoxyadenosine (3’-dA) phosphoramidate, an adenosine derivative which is isolated from Cordyceps sinensis. It acts by targeting adenosine monophosphate activated protein kinase (AMPK) and is being developed based on ProTide technology.

NuCana overview

NuCana is a clinical-stage biopharmaceutical company that develops novel and transformational medicines for the treatment of cancer. The company pipeline products include NUTIDE-302, NUTIDE-323, NUTIDE-303 and NUTIDE-701 under the clinical studies NUC-3373 and NUC-7738. The company’s product candidates treat colorectal cancer, solid tumor and lung cancer, among others. NuCana develops products based on the ProTide technology platform, which focuses on developing new-generation, anti-cancer agents. The company operates in UK and the US. NuCana is headquartered in Edinburgh, Scotland, the UK

For a complete picture of NUC-7738’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.