NUC-7738 is under clinical development by NuCana and currently in Phase II for Solid Tumor. According to GlobalData, Phase II drugs for Solid Tumor have a 10% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how NUC-7738’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

NUC-7738 overview

NUC-7738 is under development for the treatment of solid tumors including metastatic cutaneous melanoma, metastatic lung adenocarcinoma, B-cell non-Hodgkin lymphomas (NHL), Hodgkin's lymphoma, T-cell lymphomas and lymphoma. It is a protide transformation of cordycepin. It acts by targeting adenosine monophosphate activated protein kinase (AMPK). The drug candidate is developed based on ProTide technology.

NuCana overview

NuCana, formerly NuCana BioMed, is a clinical-stage biopharmaceutical company. It focuses on developing novel and transformational medicines for cancer treatments. Its key products include Acelarin, which is in phase III clinical studies, and used to treat biliary tract cancer. The company is also developing products such as NUC-3373 and NUC-7738, which are under Phase I study and used to treat solid tumors. NuCana develops products based on the ProTide technology platform, which focuses on developing new generation, anti-cancer agents. The company markets its products in the UK and the US. NuCana is headquartered in Edinburgh, the UK.

For a complete picture of NUC-7738’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.