Obecabtagene autoleucel is a gene-modified cell therapy commercialized by Autolus Therapeutics, with a leading Pre-Registration program in B-Cell Acute Lymphocytic Leukemia (B-Cell Acute Lymphoblastic Leukaemia). According to Globaldata, it is involved in 5 clinical trials, which are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of Obecabtagene autoleucels valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for Obecabtagene autoleucel is expected to reach an annual total of $432 mn by 2037 in the US based off GlobalDatas Expiry Model. The drugs revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drugs phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Obecabtagene autoleucel Overview
Obecabtagene autoleucel is under development for the treatment of relapsed or refractory CD19 positive acute lymphoblastic leukemia in adults and pediatrics, diffuse large B cell lymphoma, systemic lupus erythematosus, B-cell acute lymphoblastic leukaemia, chronic lymphocytic lymphoma, follicular lymphoma, mantle cell lymphoma, primary CNS lymphoma, Burkitt lymphoma and primary mediastinal large B-cell lymphoma. It is administered as an intravenous infusion. The therapeutic candidate constitutes patient's own T cells transduced with lentiviral vector that have been genetically modified to express CD19CAT-41BBZ targeting CD19. It was under development for the treatment of marginal zone lymphoma.
Autolus Therapeutics Overview
Autolus Therapeutics (Autolus) is a clinical-stage biopharmaceutical company. It offers programmed T-cell therapies for the treatment of hematological cancers and solid tumors. Autolus pipeline products include Obe-cel, AUTO1/22, AUTO5, AUTO6NG, AUTO7 and AUTO8. The company applies its extensive cell programming capability to develop a pipeline of precise, controlled and highly active products as it is both safe and the most therapeutically effective approach to manufacturing CAR T cells. Autolus is headquartered in London, England, the UK.
The company reported revenues of (US Dollars) US$1.7 million for the fiscal year ended December 2023 (FY2023), a decrease of 73.3% over FY2022. The operating loss of the company was US$179.7 million in FY2023, compared to an operating loss of US$143.4 million in FY2022. The net loss of the company was US$208.4 million in FY2023, compared to a net loss of US$148.8 million in FY2022.
For a complete picture of Obecabtagene autoleucels valuation, buy the drugs risk-adjusted NPV model (rNPV) here.
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