Ociperlimab is a monoclonal antibody commercialized by BeiGene, with a leading Phase III program in Squamous Non-Small Cell Lung Cancer. According to Globaldata, it is involved in 12 clinical trials, of which 10 are ongoing, and 2 are planned. GlobalData uses proprietary data and analytics to provide a complete picture of Ociperlimab’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

The revenue for Ociperlimab is expected to reach an annual total of $407 mn by 2035 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Ociperlimab Overview

Ociperlimab (BGB-A1217) is under development for the treatment of solid tumors including advanced hepatocellular carcinoma, locally advanced and metastatic non-squamous/squamous non-small cell lung cancer, recurrent or metastatic esophageal squamous cell carcinoma, cervical cancer, recurrent or metastatic HNSCC, gastric/ gastroesophageal adenocarcinoma, end stage small-cell lung cancer, relapsed or refractory diffuse large B-cell lymphoma and unspecified indication. The drug candidate is a humanized, IgG1 monoclonal antibody against T cell immunoreceptor with Ig and ITIM domains (TIGIT).

BeiGene Overview

BeiGene is a biotechnology company. It is specialized in the development and commercialization of immuno-oncology medicines to treat cancers. The company offers BRUKINSA, a BTK (Bruton’s tyrosine kinase) inhibitor against mantle cell lymphoma (MCL). BeiGene is investigating Zanubrutinib (BGB-3111), a small molecule inhibitor of BTK to treat B cell malignancies; Tislelizumab (BGB-A317), a monoclonal antibody targeting solid tumors and hematologic cancer; and Pamiparib (BGB-290) against solid tumor malignancies. It seeks to work in partnership with academia, biotechnology and pharmaceutical companies to develop treatments for cancer patients. The company has operations in the US, Australia, Germany, Spain Switzerland, and Italy. BeiGene is headquartered in Beijing, China.

The company reported revenues of (US Dollars) US$1,176.3 million for the fiscal year ended December 2021 (FY2021), compared to a revenue of US$308.9 million in FY2020. The operating loss of the company was US$1,438.7 million in FY2021, compared to an operating loss of US$1,657.7 million in FY2020. The net loss of the company was US$1,413.4 million in FY2021, compared to a net loss of US$1,596.9 million in FY2020. The company reported revenues of US$387.6 million for the third quarter ended September 2022, a decrease of 40.2% over the previous quarter.

For a complete picture of Ociperlimab’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

GlobalData

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.