Odronextamab is a monoclonal antibody commercialized by Regeneron Pharmaceuticals, with a leading Phase III program in Marginal Zone B-cell Lymphoma. According to Globaldata, it is involved in 13 clinical trials, of which 11 are ongoing, and 2 are planned. GlobalData uses proprietary data and analytics to provide a complete picture of Odronextamab’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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The revenue for Odronextamab is expected to reach an annual total of $324 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Odronextamab Overview

Odronextamab is under development for the treatment of relapsed/refractory B- cell non-Hodgkin's lymphomas including relapsed/refractory diffuse large B-cell lymphoma, relapsed/refractory follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia, Burkitt Lymphoma, primary mediastinal large B-cell lymphoma and acute lymphoblastic leukemia. The therapeutic candidate is administered intravenously. It is an anti-CD20 and anti-CD3 bi-specific monoclonal antibody. It is developed based on VelociSuite technology. It was under development for B-cell Hodgkin's lymphoma.

Regeneron Pharmaceuticals Overview

Regeneron Pharmaceuticals (Regeneron) discovers, develops, manufactures, and markets medicines for the treatment of serious medical conditions. Its products are focused on helping patients suffering from cancer, allergic and inflammatory diseases, eye diseases, metabolic and cardiovascular diseases, infectious diseases, neuromuscular diseases, hematologic conditions, pain, and rare diseases. Regeneron develops products using its Trap and VelociSuite technology platforms, which include VelocImmune, VelociGene, VelociMouse, VelociMab, Veloci-Bi, VelociT, and other related technologies. The company operates manufacturing facilities in Rensselaer, New York, and Limerick. It also collaborates with strategic partners to develop, manufacture and commercialize its products. The company sells its products to specialty pharmacies and distributors. It operates in the US, the Netherlands, Bermuda, Ireland, Spain, India, Japan and the UK. Regeneron is headquartered in Tarrytown, New York, the US.
The company reported revenues of (US Dollars) US$13,117.2 million for the fiscal year ended December 2023 (FY2023), an increase of 7.8% over FY2022. In FY2023, the company’s operating margin was 30.9%, compared to an operating margin of 38.9% in FY2022. In FY2023, the company recorded a net margin of 30.1%, compared to a net margin of 35.6% in FY2022. The company reported revenues of US$3,145 million for the first quarter ended March 2024, a decrease of 8.4% over the previous quarter.

For a complete picture of Odronextamab’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 24 July 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.