Precigen. has filed a patent for a novel method using multiple conditional, dominant, lethal gene expression systems to control insect populations. This approach reduces the risk of resistance and increases effectiveness. GlobalData’s report on Precigen gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Precigen, Cancer treatment biomarkers was a key innovation area identified from patents. Precigen's grant share as of January 2024 was 43%. Grant share is based on the ratio of number of grants to total number of patents.

Insect population control using multiple lethal gene expression systems

Source: United States Patent and Trademark Office (USPTO). Credit: Precigen Inc

A patent application (Publication Number: US20240016132A1) has been filed for a polynucleotide designed to control insect populations. The polynucleotide comprises two gene expression systems, each containing dominant lethal genes, activating transcription factors, and splice control sequences. These components work together to ensure female-specific expression of the dominant lethal genes through alternative splicing. The transcription factors can activate specific promoters, leading to the expression of non-functional proteins in females, ultimately resulting in population control.

Furthermore, the patent application includes details on the specific components of the gene expression systems, such as the promoters, splice control sequences, and enhancers. The polynucleotide also incorporates a fluorescent marker for tracking purposes. Additionally, a genetic construct for transforming insects is described, which includes the polynucleotide and transposon inverted repeats for integration into the host genome. The application also covers the use of the polynucleotide in various insect families, including Tephritidae and Drosophilidae, with a specific mention of Ceratitis capitata. A method for controlling insect populations by releasing insects containing the polynucleotide is also outlined in the patent application. Overall, the invention aims to provide a novel approach to insect population control through genetic manipulation.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies