Psilocybin is under clinical development by Compass Pathways and currently in Phase III for Treatment Resistant Depression. According to GlobalData, Phase III drugs for Treatment Resistant Depression have a 67% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData’s report assesses how Psilocybin’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Psilocybin overview

Psilocybin is under development for the treatment of treatment-resistant depressive disorder (P-TRD), autism, major depressive disorder, anorexia nervosa and body dysmorphic disorder. It is formulated as the capsule and administered by oral route. The drug candidate is a tryptamine alkaloid which is a psychedelic prodrug compound acts by targeting 5hydroxy tryptamine 1A and 2A.

Compass Pathways overview

Compass Pathways (CMPS) is a mental health care company that focuses on enhancing the lives of people suffering with mental health challenges and who do not respond to existing treatments. It is investigating a novel therapy based on its proprietary formulation of synthetic psilocybin, COMP360 in phase IIb clinical studies. The COMP360 holds Breakthrough Therapy designation from the the US Food and Drug Administration (FDA) for treatment-resistant depression (TRD) in combination with psychological support. The company operates offices in New York, the US. CMPS is headquartered in Altrincham, Cheshire, the United Kingdom.

For a complete picture of Psilocybin’s drug-specific PTSR and LoA scores, buy the report here.

GlobalData

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.