Purdue Pharma has filed a patent for a process to purify noroxymorphone by creating and isolating noroxymorphone bisulfite adduct, then regenerating purified noroxymorphone. The patent also covers a specific compound and a crystalline form of noroxymorphone bisulfite adduct monohydrate. GlobalData’s report on Purdue Pharma gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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Purifying noroxymorphone by preparing and isolating bisulfite adduct
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A patent application (Publication Number: US20230399334A1) discloses a process for preparing noroxymorphone bisulfite adduct, involving mixing an aqueous composition containing noroxymorphone with a source of sulfurous acid and isolating the adduct from the mixture. The process can also include using an acid with a bisulfite salt or a sulfite salt to form the adduct, with variations in the mixing methods. The source of sulfurous acid can be aqueous sulfurous acid, sulfur dioxide gas, or a combination of bisulfite salt and acid. The process further details the use of inorganic or organic acids, specific salts, and the presence of an organic co-solvent in the aqueous composition.
Moreover, the patent application describes the purification of noroxymorphone by forming a bisulfite adduct to remove colored impurities and then regenerating purified noroxymorphone from the adduct. The regeneration process involves adding a base to the noroxymorphone bisulfite adduct slurry to obtain noroxymorphone base, which is then isolated through filtration and drying. The purified noroxymorphone exhibits an improved colorimetric profile compared to the original compound. Additionally, the purified noroxymorphone can be used in the preparation of various pharmaceuticals such as naloxone, naltrexone, nalmefene, and nalbuphene, either as the active ingredient or in the form of pharmaceutically acceptable salts or solvates, highlighting the potential applications of the purified compound in the pharmaceutical industry.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
