Quantum-Si has been granted a patent for compositions that can detect single molecules in a sample. The patent describes a labeled molecule consisting of a reactant connected to two or more luminescent labels through a nucleic acid linker. The luminescent labels are separated by at least 5 angstroms, and can be integrated within the linker or attached via a glycolamine spacer molecule. The patent also covers methods of sequencing using these labeled nucleotides. GlobalData’s report on Quantum-Si gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Quantum-Si, optoelectronic biosensors was a key innovation area identified from patents. Quantum-Si's grant share as of June 2023 was 1%. Grant share is based on the ratio of number of grants to total number of patents.
Detection of single molecules using labeled nucleic acid linker
A recently granted patent (Publication Number: US11655504B2) describes a labeled molecule and labeled nucleotide for use in various applications. The labeled molecule comprises a reactant connected to two or more luminescent labels via a nucleic acid linker. Each luminescent label is at least 5 angstroms separated from any other luminescent label. The molecule can have a cyanine-based fluorophore integrated within the nucleic acid linker or have luminescent labels attached to the nucleic acid linker via a glycolamine spacer molecule. The labeled nucleotide, on the other hand, comprises a nucleoside polyphosphate connected to two or more luminescent labels via a nucleic acid linker. Similar to the labeled molecule, each luminescent label in the nucleotide is at least 5 angstroms separated from any other luminescent label. The nucleotide can also have a cyanine-based fluorophore integrated within the nucleic acid linker or have luminescent labels attached to the nucleic acid linker via a glycolamine spacer molecule. The nucleic acid linker in the labeled nucleotide is an oligomer that consists of at least 10 monomeric units, and it can have fewer than 150, 100, or 50 monomeric units. The attachment sites for the luminescent labels on the nucleic acid linker are at least 5 monomeric units separated from each other. The nucleotide can have a first oligonucleotide strand attached to the luminescent labels at multiple attachment sites, with each luminescent label having a steric volume that is at least 5 angstroms separated from any other luminescent label. The nucleotide can also have a second oligonucleotide strand hybridized with the first oligonucleotide strand, with the first oligonucleotide strand attached to the nucleoside polyphosphate. The attachment sites on the first oligonucleotide strand can be separated from each other by at least 5 and fewer than 50 bases, and each attachment site is at least 2 bases separated from a guanine or cytosine on the first oligonucleotide strand. Additionally, the first oligonucleotide strand can form one or more stem-loops, with the loop region of each stem-loop serving as an attachment site.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
