Rinvecalinase alfa is under clinical development by DiaMedica Therapeutics and currently in Phase III for Acute Ischemic Stroke. According to GlobalData, Phase III drugs for Acute Ischemic Stroke have a 13% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData’s report assesses how Rinvecalinase alfa’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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Rinvecalinase alfa overview
Rinvecalinase Alfa (DM-199) is under development for the treatment of diabetic nephropathy (diabetic kidney disease), other metabolic diseases, acute ischemic stroke, unspecified indication and chronic kidney diseases in patients with type-1 diabetes and vascular dementia, IgA nephropathy. The drug candidate is administered through subcutaneous and intravenous route. DM-199 is a recombinant human tissue kallikrein-1 protein known as rhKLK-1.
The drug candidate was also under development for Alzheimer's disease, rheumatoid arthritis, type 2 diabetes, type 1 diabetes, acute kidney injury and Alport syndrome.
DiaMedica Therapeutics overview
DiaMedica Therapeutics (DiaMedica), formerly DiaMedica, is a biopharmaceutical company. It develops innovative medicines for the treatment of neurological and kidney diseases. Its lead product candidate DM-199, is a human recombinant protein that treats diabetes type 1 and type 2, and associated complications including diabetic kidney disease and alport syndrome; and DM300 for treating acute pancreatitis. DiaMedica’s DM199 is also used for the treatment of diabetic nephropathy and post-insult treatment from acute ischemic stroke (AIS). The company discovers and develops novel therapies for kidney dysfunction and metabolic disorders. The company also provides clinical trial services. DiaMedica is headquartered in Minneapolis, Minnesota, the US.
For a complete picture of Rinvecalinase alfa’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
