Rivogenlecleucel is under clinical development by Bellicum Pharmaceuticals and currently in Phase II for Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia). According to GlobalData, Phase II drugs for Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia) have a 36% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Rivogenlecleucel’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Rivogenlecleucel overview
Rivogenlecleucel (BPX-501) is under development for the treatment of hematopoietic stem cell transplantation. It is administered through intravenous route. BPX-501 is a caspaCIDe candidate designed as an adjunct polyclonal donor T cell therapy administered after allogeneic HSCT. Donor T lymphocytes are transduced with a retroviral vector containing inducible caspase 9 and truncated CD19. It was also under development for the treatment of acute lymphocytic leukemia, acute myelocytic leukemia, myelodysplastic syndrome, non-Hodgkin lymphoma, unspecified hematological disorders, aplastic anemia, osteopetrosis, beta thalassemia, sickle cell disease, diamond-Blackfan anemia (congenital hypoplastic anemia), cytopenia and Fanconi anemia.
Bellicum Pharmaceuticals overview
Bellicum Pharmaceuticals, Inc. (Bellicum) is a clinical-stage biopharmaceutical company, that develops cellular immunotherapies for the treatment of cancer. The company develops its product candidates through its chemical induction of dimerization technology platforms in the areas of cellular immunotherapy including hematopoietic stem cell transplantation, CAR T cell therapy and TCR cell therapies. Its GoCAR™ technology builts a enhance effector cell proliferation and functional persistence and is designed to enlist wider immune cell engagement to target resistant tumor cells. Bellicum’s lead pipeline candidate includes BPX-501, an adjunct T-cell therapy intended for the treatment of leukemias, lymphomas and genetic blood diseases. The company also develops pipeline products for the treatment of solid tumors, hematological cancers and others. Bellicum is headquartered in Houston, Texas, the US.
For a complete picture of Rivogenlecleucel’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
