RZ-402 is a small molecule commercialized by Rezolute, with a leading Phase II program in Diabetic Macular Edema. According to Globaldata, it is involved in 3 clinical trials, which were completed. GlobalData uses proprietary data and analytics to provide a complete picture of RZ-402’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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Data Insights Net Present Value Model: Rezolute Inc's RZ-402

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The revenue for RZ-402 is expected to reach an annual total of $69 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

RZ-402 Overview

RZ-402 is under development for the treatment of diabetic macular edema (diabetes-induced retinal vascular permeability). It is administered through oral route. The drug candidate targets plasma kallikrein. It was also under development for treatment of intracerebral hemorrhage (hyperglycemia-induced hematoma expansion) and diabetic retinopathy (DR). 

Rezolute Overview

Rezolute, is a clinical-stage biopharmaceutical company that carries out the development of innovative drug therapies for the treatment of metabolic diseases related to chronic glucose imbalance. Its pipeline product portfolio includes RZ402, RZ358. RZ358 is an intravenous monoclonal antibody which is used for the treatment of conditions characterized by excessive insulin levels and is developing to treat hyperinsulinism and low blood sugar characteristic of diseases such as congenital hyperinsulinism. The company also offers RZ402 which is a potent plasma kallikrein inhibitor used for the treatment of diabetic macular edema (DME). Rezolute is headquartered in Redwood City, California, the US.
The operating loss of the company was US$56 million in FY2023, compared to an operating loss of US$43.4 million in FY2022. The net loss of the company was US$51.8 million in FY2023, compared to a net loss of US$41.1 million in FY2022.

For a complete picture of RZ-402’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.