Sichuan Kelun Pharmaceutical has been granted a patent for a preparation method of an antibody-drug conjugate represented by Formula (I), including salts, stereoisomers, and solvates. GlobalData’s report on Sichuan Kelun Pharmaceutical gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Sichuan Kelun Pharmaceutical, was a key innovation area identified from patents. Sichuan Kelun Pharmaceutical's grant share as of February 2024 was 69%. Grant share is based on the ratio of number of grants to total number of patents.

Preparation method for antibody-drug conjugate

Source: United States Patent and Trademark Office (USPTO). Credit: Sichuan Kelun Pharmaceutical Co Ltd

A recently granted patent (Publication Number: US11903948B2) discloses a preparation method for an antibody-drug conjugate represented by Formula (I) or its derivatives, salts, stereoisomers, or solvates. The method involves specific parameters such as the presence of Y as CR1, R1 as H, and a being 2, 3, or 4, among others. Additionally, the antibody-drug conjugate is further defined by Formula (I-1) and the possible variations in R6, which can be H, C1-C8 alkyl, C3-C8 cycloalkyl, or C6-C14 aryl, with optional halogen substitutions.

The patent's claims outline a detailed process for the preparation of a specific antibody-drug conjugate, emphasizing the structural requirements and variations allowed within the formula. By specifying parameters such as the nature of Y, R1, and R6, as well as the possible halogen substitutions, the patent provides a comprehensive guide for producing the desired conjugate. This method offers a precise and controlled approach to synthesizing the antibody-drug conjugate, ensuring consistency and reproducibility in its preparation for potential pharmaceutical applications.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies