SpringWorks Therapeutics. has filed a patent for improved methods of treatment with nirogacestat. The claim numbers 1-44 have been canceled. GlobalData’s report on SpringWorks Therapeutics gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on SpringWorks Therapeutics, Personalized cancer vaccines was a key innovation area identified from patents. SpringWorks Therapeutics's grant share as of January 2024 was 6%. Grant share is based on the ratio of number of grants to total number of patents.
Improved treatment methods using nirogacestat
A recently filed patent (Publication Number: US20240033251A1) discloses a method for treating desmoid tumors in patients by administering an oral dosage of nirogacestat or its pharmaceutically acceptable salt. The dosage is designed to achieve a maximum concentration (Cmax) of less than 1000 ng/mL upon initial oral administration. The method includes options for once-daily or twice-daily administration, specifically targeting progressive desmoid tumors. The treatment aims to provide a meaningful reduction in the risk of disease progression, improvement in progression-free survival, and significant enhancements in objective response rate and quality of life assessments.
Furthermore, the patent outlines a method for treating desmoid tumors by administering an oral dosage of nirogacestat or its salt, ensuring an area under the concentration-time curve (AUCinf) of less than 4000 ng·h/mL upon initial oral administration to human subjects. Similar to the previous method, this approach offers flexibility in dosing frequency, targeting progressive desmoid tumors. The treatment is expected to deliver positive outcomes such as reducing the risk of disease progression, enhancing progression-free survival, and improving objective response rate and quality of life assessments. These methods represent innovative approaches in the treatment of desmoid tumors, potentially offering new avenues for managing this challenging medical condition.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
