SYNCAR-001 is under clinical development by Synthekine and currently in Phase I for Refractory Chronic Lymphocytic Leukemia (CLL). According to GlobalData, Phase I drugs for Refractory Chronic Lymphocytic Leukemia (CLL) have a 75% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how SYNCAR-001’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

SYNCAR-001 overview

SYNCAR-001 is under development for the treatment of unspecified B-cell lymphomas, relapsed/refractory hematologic malignancies, including chronic lymphocytic lymphoma and selected non-Hodgkin’s lymphoma and hepatocellular cancer. It comprises of T cells genetically modified to express chimeric antigen receptor (CAR) that targets cells expressing CD19. The drug candidate is developed based on synthekine platform. It is administered through intravenous route.

Synthekine overview

Synthekine is a biotherapeutics company focused on of novel specific, selective and potent cytokine therapies for the treatment of cancer and autoimmune disorders. The company is investigating its lead programs candidate in IND-enabling development STK-012, an engineered Interleukin-2 (IL-2) partial agonist targeting cancer, STK-009 and SYNCAR-001, an orthogonal IL-2 ligand designed to selectively activate CAR-Ts and other adoptive cell therapies (ACTs) in vivo to improve efficacy CAR-Ts and other ACTs by data evaluation. Synthekine is headquartered in Menlo Park, California, the US.

For a complete picture of SYNCAR-001’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.