TAK-500 is under clinical development by Takeda Pharmaceutical and currently in Phase I for Malignant Mesothelioma. According to GlobalData, Phase I drugs for Malignant Mesothelioma have a 77% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how TAK-500’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
TAK-500 is under development for the treatment of metastatic solid tumors including adenocarcinoma of the gastroesophageal junction, esophageal cancer, gastric cancer, pancreatic adenocarcinoma, hepatocellular carcinoma (HCC), non-squamous non-small cell lung cancer (NSCLC), head and neck cancer squamous cell carcinoma (SCCHN), renal cell carcinoma, nasopharyngeal cancer, mesothelioma and triple-negative breast cancer (TNBC). The drug candidate acts by targeting stimulator of interferon genes (STING). It is an antibody drug conjugate (ADC) STING agonist with a cyclic purine dinucleotide payload. It is administered through intravenous route.
Takeda Pharmaceutical overview
Takeda Pharmaceutical (Takeda) is a research-based pharmaceutical company which focuses on the discovery, development, manufacturing, marketing, commercialization, import and export of pharmaceutical drugs. The company offers products in the areas of rare diseases, gastrointestinal, oncology, neuroscience, vaccines, and plasma-derived therapies. Takeda has facilities in Japan, Argentina, Brazil, Mexico, the US, Denmark, Norway, Europe, Poland, Russia, Spain, Switzerland, China, India, and Canada among others. It markets products directly and through a network of wholesale distributors, retail chains and other purchasing groups worldwide. Takeda has partnership with academic institutions, small biotech, and large pharmaceutical companies. It has presence in the Americas, Europe, and Asia, among others. Takeda is headquartered in Tokyo, Japan.
For a complete picture of TAK-500’s drug-specific PTSR and LoA scores, buy the report here.