TC-110 is under clinical development by Adaptimmune Therapeutics and currently in Phase II for Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia). According to GlobalData, Phase II drugs for Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia) have a 36% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how TC-110’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
TC-110 overview
TC-110 is under development for the treatment of relapsed and refractory acute lymphoblastic leukemia, mantle cell lymphoma and follicular lymphoma. The drug candidate is composed of T-cells expressing T-cell receptors (TCR) developed based on TRuC-T platform technology. It acts by targeting cells expressing CD19. The drug candidate was also under development for burkitt lymphoma and chronic lymphocytic leukemia, relapsed and refractory forms of diffuse large B cell lymphoma and primary mediastinal B-cell lymphoma.
Adaptimmune Therapeutics overview
Adaptimmune Therapeutics (Adaptimmune) is a clinical-stage biopharmaceutical company that develops innovative T-cell therapy products for the treatment of cancer. The company product pipeline includes afami cel, ADP-A2M4CD8 and ADP-A2AFP. It treats synovial sarcoma, head and neck, urothelial, esophageal, EGJ cancer and hepatocellular carcinoma. Adaptimmune has collaborated with Alpine Immune Sciences, Cell and Gene Therapy Catapult, Center for Cancer ImmunTherapy, Genentech and MD Anderson Cancer Center, among others. The company has operations across the US and the UK. Adaptimmune is headquartered in Abingdon, Oxfordshire, the UK.
For a complete picture of TC-110’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
