Tiragolumab is a monoclonal antibody commercialized by F. Hoffmann-La Roche, with a leading Phase III program in Non-Small Cell Lung Cancer. According to Globaldata, it is involved in 44 clinical trials, of which 3 were completed, 30 are ongoing, 9 are planned, and 2 were terminated. GlobalData uses proprietary data and analytics to provide a complete picture of Tiragolumab’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for Tiragolumab is expected to reach an annual total of $500 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Tiragolumab (RG-6058, MTIG-7192A, anti-TIGIT) is under development for the treatment of advanced or metastatic hepatocellular carcinoma (HCC), melanoma, bladder cancer, renal cell carcinoma, advanced rectal cancer, advanced or metastatic solid tumors, head and neck squamous cell carcinoma (SCCHN) involving the oropharynx, oral cavity, larynx, or hypopharyngeal cancers, metastatic esophageal squamous cell carcinoma, gastric cancer or adenocarcinoma of gastroesophageal junction, gastroesophageal junction carcinomas, triple negative breast cancer, B-Cell Non-Hodgkin Lymphoma, locally advanced, recurrent, or metastatic incurable tumors, adenocarcinoma of the cervix, small-cell lung cancer, brain metastases and non-small cell lung cancer. The drug candidate is administered as an intravenous (IV) infusion. It acts by targeting TIGIT protein.
It was also under development for the treatment of relapsed/refractory multiple myeloma, relapsed/refractory B-cell non-Hodgkin lymphoma
F. Hoffmann-La Roche Overview
F. Hoffmann-La Roche (Roche) is a biotechnology company that develops drugs and diagnostics to treat major diseases. It provides medicines for the treatment of cancer, other auto-immune diseases, central nervous system disorders, ophthalmological disorders, infectious diseases, and respiratory diseases. The company also offers in vitro diagnostics, tissue-based cancer diagnostics, and diabetes management solutions. Roche conducts research to identify novel methods to prevent, diagnose, and treat diseases. The company offers its products and services to hospitals, healthcare professionals, commercial laboratories, researchers, and pharmacists. Together with its subsidiaries and partners, the company has operations in various countries. Roche is headquartered in Basel, Switzerland.
The company reported revenues of (Swiss Francs) CHF63,281 million for the fiscal year ended December 2022 (FY2022), an increase of 0.8% over FY2021. In FY2022, the company’s operating margin was 27.6%, compared to an operating margin of 28.9% in FY2021. In FY2022, the company recorded a net margin of 19.6%, compared to a net margin of 22.2% in FY2021.
For a complete picture of Tiragolumab’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.