Tisotumab vedotin is under clinical development by Genmab and currently in Phase II for Recurrent Head And Neck Squamous Cell Carcinoma. According to GlobalData, Phase II drugs for Recurrent Head And Neck Squamous Cell Carcinoma have a 33% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Tisotumab vedotin’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Tisotumab vedotin overview

Tisotumab Vedotin (Tivdak) is a tissue factor-directed antibody-drug conjugate. It is formulated as solution for intravenous use. Tivdak is indicated for the treatment of adult patients with recurrent or metastatic cervical cancer with disease progression on or after chemotherapy.

Tisotumab vedotin is under development for the treatment of cancers of the cervix, endometrium, bladder, squamous cell carcinoma of the head and neck (SCCHN), castration-resistant prostate cancer, non-small cell lung cancer, epithelial ovarian cancer, Platinum-resistant ovarian cancer, peritoneal cancer, fallopian tube cancer, metastatic colorectal, metastatic and locally advanced solid tumors and pancreatic cancer. It is administered through intravenous route. HuMax-TF is a fully human antibody conjugated targeted to cells expressing CD142 (Tissue Factor or Thromboplastin). HuMax-TF is developed based on ADC technology.

Genmab overview

Genmab is a biotechnology company that develops differentiated human antibody therapies for the treatment of cancer and other diseases. The company’s marketed antibodies include ofatumumab (Kesimpta) for the treatment of relapsing multiple sclerosis, daratumumab (Darzalex) for the treatment of AL amyloidosis and multiple myeloma, and teprotumumab (Tepezza) for thyroid eye disease. Its products are based on proprietary antibody technologies, namely, HexaBody, DuoBody, DuoHexaBody, and HexElect technologies. The company works in partnership with various pharmaceutical and biotechnology companies for the co-development and commercialization of antibody-based products. It operates in Denmark, the Netherlands, Japan, and the US. Genmab is headquartered in Copenhagen, Denmark.

For a complete picture of Tisotumab vedotin’s drug-specific PTSR and LoA scores, buy the report here.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.