TN-301 is a small molecule commercialized by Tenaya Therapeutics, with a leading Phase I program in Diastolic Heart Failure (HFpEF). According to Globaldata, it is involved in 1 clinical trial, which was completed. GlobalData uses proprietary data and analytics to provide a complete picture of TN-301’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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The revenue for TN-301 is expected to reach an annual total of $154 mn by 2037 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

TN-301 Overview

TN-301 (TYA-11631) is under development for the treatment of heart failure (HF) with preserved ejection fraction (HFpEF) and genetic dilated cardiomyopathy (gDCM). It is administered by oral route. The therapeutic candidate acts by inhibiting histone deacetylase 6 (HDAC6).

Tenaya Therapeutics Overview

Tenaya Therapeutics is a biopharmaceutical company that develops novel therapies to treat heart diseases. The company utilizes its cellular regeneration, gene therapy, and precision medicine product platforms for drug development. Its product pipeline includes TN-201 to treat hypertrophic cardiomyopathy; TN-401 for treatment of cardiomyopathy; TN-301 targeting diastolic heart failure and dilated cardiomyopathy; and DWORF to treat congestive heart failure. Tenaya Therapeutics is also developing other drug candidates to treat dilated cardiomyopathy, heart failure, heart failure with preserved ejection fraction (HFrEF), hypertrophic cardiomyopathy, and genetic and idiopathic cardiomyopathies. The company works in collaboration with Gladstone Institutes and University of Texas Southwestern Medical Center. Tenaya Therapeutics is headquartered in South San Francisco, California, the US.
The operating loss of the company was US$125.6 million in FY2022, compared to an operating loss of US$72.8 million in FY2021. The net loss of the company was US$123.7 million in FY2022, compared to a net loss of US$72.7 million in FY2021.

For a complete picture of TN-301’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.