TransCon TLR7/8 Agonist is under clinical development by Ascendis Pharma and currently in Phase II for Melanoma. According to GlobalData, Phase II drugs for Melanoma have a 27% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how TransCon TLR7/8 Agonist’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
TransCon TLR7/8 Agonist overview
Small molecule is under development for the treatment of solid tumors including head and neck squamous-cell carcinoma (HNSCC), other HPV-associated cancers, melanoma, cutaneous squamous cell carcinoma (cSCC), colon cancer. The drug candidate is a long acting prodrug of resiquimod administered through intratumoral route. It acts by targeting toll-like receptor (TLR) 7 and 8. It is developed based on the TransCon technology platform.
Ascendis Pharma overview
Ascendis Pharma is a biopharmaceutical company that focuses on developing drugs for endocrinology and oncology indications. It is investigating TransCon hGH, a long-acting human growth hormone prodrug targeting GHD (growth hormone deficiency); TransCon PTH drug to treat hypoparathyroidism by restoring physiologic levels of PTH (parathyroid hormone); and TransCon CNP, a CNP (C-type natriuretic peptide) drug against achondroplasia (ACH). It is also evaluating TransCon TLR (toll-like receptor) 7/8 agonist, and TransCon IL-2 ß/?, an interleukin-2 variant that activates the IL-2 receptor beta/gamma (IL-2Rß/?) for the treatment of cancer. Ascendis Pharma utilizes its proprietary TransCon technology platform to develop its drugs. The company has its operations in the US, Germany and Denmark. Ascendis Pharma is headquartered in Copenhagen, Denmark.
For a complete picture of TransCon TLR7/8 Agonist’s drug-specific PTSR and LoA scores, buy the report here.