Translate Bio has been granted a patent for a method to quantitate mRNA capping efficiency in mRNA synthesized in vitro. The method involves providing a cap specific binding substance to form a complex with capped mRNA and quantitatively determining the amount of the complex. GlobalData’s report on Translate Bio gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Translate Bio, was a key innovation area identified from patents.

Method of quantifying mrna capping efficiency during manufacturing

Source: United States Patent and Trademark Office (USPTO). Credit: Translate Bio Inc

A recently granted patent (Publication Number: US11920182B2) discloses a method for manufacturing mRNA with quantified capping efficiency. The method involves in vitro transcribing mRNA from a DNA template containing a promoter, incorporating a cap analog, and quantifying the capping efficiency by forming a complex between the capped mRNA and a cap specific binding substance. The amount of the complex is then quantitatively determined compared to a control, allowing for the manufacturing of mRNA with precise capping efficiency levels.

The patent claims detail various aspects of the method, including the structure of the cap analog, different types of cap analogs that can be used, the cap specific binding substances such as proteins or antibodies, and the methods for quantitatively determining the amount of the complex. The claims also cover the quantification of mRNA capping efficiency by measuring the absolute amount or percentage of capped mRNA in the sample. This method provides a systematic approach to manufacturing mRNA with controlled capping efficiency, which is crucial for various applications in biotechnology and therapeutics.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies