TTI-101 is under clinical development by Tvardi Therapeutics and currently in Phase II for Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer). According to GlobalData, Phase II drugs for Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer) have a 49% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how TTI-101’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
TTI-101 overview
TTI-101 is under development for the treatment of solid tumors including breast cancer, metastatic hormone receptor-positive and HER2-negative breast cancer, head and neck squamous cell carcinoma, non-small cell lung cancer, metastatic hepatocellular carcinoma, colorectal cancer, gastric adenocarcinoma and melanoma, skin, liver, idiopathic pulmonary fibrosis, scleroderma and oropharyngeal cancer. It is administered intravenously and orally (in the form of hard capsule). The drug candidate act by targeting signal transducer and activator of transcription (STAT) 1 and 3. It was also under development for the treatment of inflammatory bowel disease, unspecified cancers, cachexia and inflammation.
Tvardi Therapeutics overview
Tvardi Therapeutics is developing oral small molecule therapeutics for the treatment of fibrosis-driven diseases. The company is headquartered in Sugar Land, Texas, the US.
For a complete picture of TTI-101’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
