Vebreltinib ER is under clinical development by Apollomics and currently in Phase II for Colon Cancer. According to GlobalData, Phase II drugs for Colon Cancer does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Vebreltinib ER LoA Report. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Vebreltinib ER overview

Vebreltinib ER (Vambiru) is a potent, small molecule, orally bioavailable, and highly selective anticancer agent. It is formulated as an enteric-coated capsule for the oral route of administration. Vambiru is indicated to treat first-line, locally advanced or metastatic non-leukemia patients with mesenchymal-to-epithelial transition factor (MET) exon 14 skipping, non-small cell lung cancer (NSCLC).

APL-101 (CBT-101) is under development for the treatment of c-Met dysregulation advanced solid tumors such as high-grade gliomas, non-small cell lung cancer, gastric cancer, gastroesophageal junction adenocarcinoma, renal cell carcinoma, primary CNS tumor, gastric cancer, hepatic cancer, recurrent glioblastoma multiforme, pancreatic cancer, colon cancer, leptomeningeal disease (neoplastic meningitis, leptomeningeal carcinomatosis), esophageal cancer, glioblastoma multiforme. The therapeutic candidate is administered orally as a enteric coated capsule. It acts by targeting the c-Met (hepatocyte growth factor receptor). It was also under development for the treatment of advanced or metastatic hepatocellular carcinoma, and renal cell carcinoma.

Apollomics overview

Apollomics is a biotechnology company that discovers and develops oncology therapies. It is investigating APL-101, a novel small molecule c-Met inhibitor (c-METi) that targets the c-Met-dysregulated pathway in gastric, hepatic, pancreatic and lung tumors; and APL-102, an oral multi-kinase inhibitor (mKi) targeting receptor tyrosine kinase (RTKs) and serine or threonine-kinases in liver, breast, colorectal, gastric cancers. The company is also evaluating APL-106 against acute myeloid leukemia (AML); APL-108 to treat multiple myeloma (MM); APL-501 and APL-102 targeting solid tumors; APL-502 and APL-801 against multiple tumors; and APL-810 for gastroenterological cancers. It operates in Taiwan and the US. Apollomics is headquartered in Foster City, California, the US.

For a complete picture of Vebreltinib ER’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.