Wave Life Sciences has been granted a patent for a method of synthesizing oligonucleotides with higher yields and purities. The method involves preparing phosphoramidites and removing byproducts without contact with an aqueous solution, resulting in improved efficiency. GlobalData’s report on Wave Life Sciences gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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Data Insights Wave Life Sciences Ltd - Company Profile

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According to GlobalData’s company profile on Wave Life Sciences, siRNA gene silencing was a key innovation area identified from patents. Wave Life Sciences's grant share as of February 2024 was 55%. Grant share is based on the ratio of number of grants to total number of patents.

A recently granted patent (Publication Number: US11873316B2) discloses a method for preparing a phosphoramidite, involving steps such as providing a preparation containing the phosphoramidite product and reaction byproducts, followed by a filtration process to reduce the level of byproducts in the filtrate. The method ensures that the phosphoramidite product is not exposed to water beyond a certain limit to maintain its integrity. The structure of the phosphoramidite is defined by a specific formula, and the method aims to achieve a high purity level of the final product.

The method outlined in the patent includes various specific claims, such as the presence of solids in the preparation along with the phosphoramidite product, purification using silica gel column chromatography treated with anhydrous acetonitrile, and different variations in the chemical structure of the phosphoramidite. The claims also specify purity levels of the prepared phosphoramidite, ranging from 90% to 96% or more, indicating a focus on obtaining a highly pure final product. By following the steps outlined in the patent, the method aims to efficiently prepare phosphoramidite while minimizing the presence of unwanted byproducts, ultimately leading to a high-quality end product with a specified level of purity.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies