Wave Life Sciences has been granted a patent for a method to synthesize oligonucleotides with higher yields and purities. The method involves preparing phosphoramidites and removing byproducts through a filtration step without contact with an aqueous solution, resulting in improved product quality. GlobalData’s report on Wave Life Sciences gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Wave Life Sciences, siRNA gene silencing was a key innovation area identified from patents. Wave Life Sciences's grant share as of January 2024 was 24%. Grant share is based on the ratio of number of grants to total number of patents.
A recently granted patent (Publication Number: US11873316B2) discloses a method for preparing a phosphoramidite, involving steps such as providing a preparation containing the phosphoramidite product and reaction byproducts, followed by a filtration process to reduce the level of byproducts in the filtrate. The method ensures that the phosphoramidite product is not exposed to water beyond a certain limit to maintain its integrity. The phosphoramidite product is characterized by a specific chemical structure outlined in the patent.
Furthermore, the method includes additional steps such as purifying the phosphoramidite product using silica gel column chromatography treated with anhydrous acetonitrile. Various variations in the chemical structure of the phosphoramidite product are also mentioned in the claims, along with requirements for achieving different levels of purity in the final product. The patent emphasizes the importance of maintaining high purity levels, with claims specifying purity thresholds of 90%, 95%, and 96% or more for the prepared phosphoramidite. These detailed steps and criteria outlined in the patent aim to provide a reliable and efficient method for preparing phosphoramidite with high purity levels for various applications in the field.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
