WuXi AppTec has been granted a patent for a process to prepare a dichloroacetic acid composition with less than 1000 ppm glyoxylic acid. The method involves mixing a dichloroacetic acid material with a glyoxylic acid capture reagent. This innovation allows for accurate measurement of glyoxylic acid concentration. GlobalData’s report on WuXi AppTec gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on WuXi AppTec, AI-assisted drug screening was a key innovation area identified from patents. WuXi AppTec's grant share as of February 2024 was 37%. Grant share is based on the ratio of number of grants to total number of patents.

Process for preparing dichloroacetic acid composition with low glyoxylic acid

Source: United States Patent and Trademark Office (USPTO). Credit: WuXi AppTec Co Ltd

A recently granted patent (Publication Number: US11873318B2) discloses a process for preparing a dichloroacetic acid composition with less than 1000 ppm glyoxylic acid. The method involves mixing a dichloroacetic acid material containing more than 1000 ppm glyoxylic acid with a glyoxylic acid capture reagent to achieve the desired composition. The capture reagent can be selected from various compounds such as amino acids, chemicals with bifunctional or multifunctional groups, hydroxylamine compounds, reductants, or their mixtures.

Furthermore, the patent describes a method for synthesizing oligonucleotides using a substantially pure dichloroacetic acid with less than 50 ppm glyoxylic acid. This involves mixing the pure dichloroacetic acid with a protected oligonucleotide containing an acid labile protecting group to produce a deprotected oligonucleotide. The process includes reducing the glyoxylic acid level in the starting dichloroacetic acid composition to less than 50 ppm by reacting it with a glyoxylic acid capture reagent. The protected oligonucleotide can be bound to a solid support, and the acid labile protecting group is typically a trityl group. The patent also outlines a method for analyzing and reducing the glyoxylic acid content in the dichloroacetic acid composition, emphasizing the importance of maintaining low levels of glyoxylic acid for specific applications.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies