WuXi Biologics Cayman has been granted a patent for a Raman spectroscopy integrated perfusion cell culture system. The system includes a bioreactor with ports for feeding nutrient materials, auto-bleeding, and continuous harvesting, as well as a Raman analyzer with probes to collect Raman spectrum and a host computer to convert it into values. A controller is used to compare the values with preset parameters and adjust the feeding rate and auto-bleeding accordingly. This system allows for monitoring and auto-controlling of perfusion cell culture. GlobalData’s report on WuXi Biologics Cayman gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on WuXi Biologics Cayman, Personalized cancer vaccines was a key innovation area identified from patents. WuXi Biologics Cayman's grant share as of September 2023 was 18%. Grant share is based on the ratio of number of grants to total number of patents.
Raman spectroscopy integrated perfusion cell culture system
A recently granted patent (Publication Number: US11774287B2) describes a Raman spectroscopy integrated perfusion cell culture system for monitoring and auto-controlling perfusion cell culture. The system includes a bioreactor with an interior chamber for cell culture, ports for feeding nutrient materials and auto-bleeding, and a cell retention system for continuous harvesting. A Raman analyzer is also included, with one or more Raman probes immersed in the bioreactor to collect Raman spectra. A host computer receives and converts the spectra into biochemical parameter values. The system further includes a controller that compares the values with preset parameters and adjusts the feeding rate and auto-bleeding based on the results.
The patent also describes additional features of the system, such as a product harvest reservoir, a rotatable shaft coupled to an agitator in the bioreactor, and the use of multiple Raman probes to measure different signals. The Raman probes collect spectra by detecting the intensity of scattered light in the bioreactor after exposure to a periodic beam of light. A laser-emitting module with an excitation wavelength of 785 nm is used, and a light-impermeable cover is provided to protect the bioreactor during laser emission.
The collected Raman spectra can be correlated to various biochemical indices, including viable cell density, cell diameter, pH, pCO2, pO2, Na+ ions, K+ ions, glucose, glutamine, glutamate, lactate, ammonium ions, titer, and osmolality. The system is versatile and can be used to incubate various types of cells, including animal cells, plant cells, bacteria cells, and fungi cells. The process for monitoring and auto-controlling perfusion cell culture using this system involves culturing cells in a bioreactor, collecting Raman spectra, converting them to biochemical indices, and adjusting the feeding and auto-bleeding rates based on the results. Continuous harvesting of cell products and maintaining cells based on their sizes can also be achieved using a cell retention system.
Overall, this patented Raman spectroscopy integrated perfusion cell culture system offers a comprehensive solution for monitoring and controlling cell culture processes. Its ability to collect Raman spectra and convert them into biochemical indices allows for real-time monitoring and adjustment of nutrient feeding and auto-bleeding rates. The system's versatility in incubating different types of cells and its potential for continuous product harvesting make it a valuable tool in biotechnology and pharmaceutical research.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
