XW-004 is under clinical development by Sciwind Biosciences and currently in Phase I for Obesity. According to GlobalData, Phase I drugs for Obesity have a 59% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how XW-004’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

XW-004 overview

XW-004 is under development for the treatment of nonalcoholic steatohepatitis (NASH), obesity and type 2 diabetes. It is administered through oral route. The drug candidate acts by targeting glucagon like peptide 1 receptor (GLP1R). The drug candidate is being developed based on polypeptide or recombinant protein preparation platform technology. 

It was also under development for the treatment of liver fibrosis.

Sciwind Biosciences overview

Sciwind Biosciences (Sciwind) is a clinical-stage biopharmaceutical company. It focuses on the discovery and development of monotherapy and combination treatments to treat metabolic diseases. The company’s product pipeline includes XW003, injectable GLP-1 analogs; XW004, an oral formulation of GLP-1 peptide; XW014, A GLP-1R agonist; and XW003 and XW0017, a GLP-1 and GIP combination for the treatment of diabetes, obesity, and non-alcoholic steatohepatitis (NASH). Sciwind is also investigating XW010, XW013, and XW015 drug programs for undisclosed targets. The company operates a research and development center in Beijing, China. It has a presence in China and the US. Sciwind is headquartered in Hangzhou, Zhejiang, China.

For a complete picture of XW-004’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.