Yuhan. has filed a patent for a method of isolating nucleic acid using a pH difference between buffers. The process involves binding nucleic acid to silica magnetic particles, washing in an acidic buffer, and eluting in a basic buffer. This method offers quicker and more efficient isolation compared to traditional methods. GlobalData’s report on Yuhan gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Yuhan, Cancer treatment biomarkers was a key innovation area identified from patents. Yuhan's grant share as of January 2024 was 33%. Grant share is based on the ratio of number of grants to total number of patents.

Method for isolating nucleic acid using ph difference between buffers

Source: United States Patent and Trademark Office (USPTO). Credit: Yuhan Corp

A newly filed patent (Publication Number: US20240002833A1) describes a method for isolating nucleic acids using a difference in pH between buffers. The process involves binding nucleic acids to silica magnetic particles in a sample containing the nucleic acid using specific binding buffers, washing the magnetic particles in an acidic pH buffer, and then separating the particles to elute the nucleic acid in a basic pH elution buffer. Notably, the method does not involve an alcohol precipitation step, and the magnetic particles used are of a specific size range (50 nm to 1 µm) and coated with siliceous materials like silica, quartz, or silicon.

Furthermore, the patent claims specify that the method is applicable to isolating both DNA and RNA, utilizing changes in pH throughout the process. Steps involving the application of a magnetic field using a magnet are crucial in the washing and separation stages. The method also includes specific pH ranges for the binding buffer (pH 1 to 6), acidic wash solution (pH 4 to 6.5), and basic elution buffer (pH 8.0 to 10.0). Additionally, the binding buffer may contain an acidic protease or proteinase K to aid in the isolation process. Overall, this patent introduces a novel approach to nucleic acid isolation that leverages pH differentials and magnetic particles for efficient and effective extraction.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies