Zhejiang Huahai Pharmaceutical has patented a method for producing citalopram diol with high selectivity and yield, low environmental impact, and suitable for industrial production. The process involves mixing Grignard reagents with raw materials in a controlled environment to obtain a high-quality product. GlobalData’s report on Zhejiang Huahai Pharmaceutical gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Zhejiang Huahai Pharmaceutical, Cancer treatment biomarkers was a key innovation area identified from patents. Zhejiang Huahai Pharmaceutical's grant share as of January 2024 was 37%. Grant share is based on the ratio of number of grants to total number of patents.
A recently granted patent (Publication Number: US11845710B2) discloses a method for the continuous preparation of citalopram diol or a citalopram diol salt. The method involves several steps, including preparing organic solvent feed liquid containing 5-cyanophthalide, mixing it with a mixed feed liquid containing Grignard reagents, reacting the resulting solution in a reactor to obtain citalopram diol, and optionally post-treating the solution to obtain the salt form. The patent outlines specific conditions for the molar concentrations of reactants, types of organic solvents used, temperature ranges, and mixing times to achieve the desired product efficiently.
Furthermore, the patent details the use of temperature-controllable micromixers for mixing the feed liquids, various types of reactors suitable for the reaction process, and specific post-treatment steps for obtaining the citalopram diol salt. The method allows for continuous introduction of feed liquids into the micromixer and subsequent reaction in the reactor, streamlining the production process. Additionally, the post-treatment steps involve quenching, extraction, acidizing, crystallizing, centrifuging, and drying to obtain the final product. The patent also specifies the types of organic solvents, acids, and extraction solvents that can be used in the process, along with the different forms of citalopram diol salt that can be obtained, such as hydrochloride, hydrobromide, sulfate, or phosphate.
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