Zhejiang Huahai Pharmaceutical has patented a method for preparing pregabalin using a biological enzyme process. The method involves producing specific compounds through enzyme reactions and configuration inversions, resulting in the final product. GlobalData’s report on Zhejiang Huahai Pharmaceutical gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Zhejiang Huahai Pharmaceutical, Cancer treatment biomarkers was a key innovation area identified from patents. Zhejiang Huahai Pharmaceutical's grant share as of February 2024 was 52%. Grant share is based on the ratio of number of grants to total number of patents.
Method for preparing pregabalin using biological enzymes
A recently granted patent (Publication Number: US11919835B2) discloses a method for preparing pregabalin, a pharmaceutical compound, through a series of specific reactions involving biological enzymes and isomerases. The method involves reacting a compound of formula (I) with a biological enzyme in a first solvent to produce a target compound of formula (III) and a by-product of formula (II). The by-product is then reacted with an isomerase in a second solvent to perform a configuration inversion, resulting in a compound of formula (IV), which is further reacted with the biological enzyme in a third solvent to yield the target compound of formula (III).
The patent claims also detail specific variations in the method, such as the use of a lipase as the hydrolase, with options including mold lipase, yeast lipase, or bacterial lipase from various sources. Additionally, the isomerase used in the process is specified to be an epimerase, with examples provided from a group including glucose isomerase, sucrose isomerase, and others. The patent further outlines the possible forms of the biological enzyme and isomerase, such as immobilized enzyme particles or enzyme powder, and provides details on the solvent systems, temperature ranges, and time durations for the reactions involved in the preparation of pregabalin.
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