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PROTAC Building Blocks

By Alberta Research Chemicals

Targeted protein degradation (TDP) has been an attractive concept in the drug discovery to selectively remove the disease-causing proteins from the system, and remained as academic interest for several decades until the recent discovery of small molecule proteolysis-targeting chimera (PROTAC) protein degraders.

This PROTAC technology has been widely used both in academia and industry in the last 20 years and in 2020, provided the first clinical proof-of-concept.

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