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Gene genie: can CRISPR-Cas9 deliver on its promise to transform genome therapy?

Experimental treatments based on CRISPR-Cas9 gene editing technology are at a crossroads, with the first European trial now enrolling patients and new clinical applications and delivery methods steadily emerging. It’s not all good news though; two studies in 2018 found that a majority of patients had T-cell immunity against a type of Cas9. Sally Turner investigates at this important juncture.

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