Aduro has announced it has initiated its Phase 1b study of its ADU-214 drug in combination with nivolumab to treat advanced lung cancer. Credit: Pixabay.

Immunotherapy company Aduro Biotech has announced it has initiated its Phase 1b study of its ADU-214 drug in combination with nivolumab to treat advanced metastatic non-small cell lung cancer.

ADU-214 is based on Aduro’s live, attenuated double-deleted Listeria (LADD) technology platform. Johnson and Johnson subsidiary Janssen and Aduro signed an agreement in 2014 for the global licensing of ADU-214 and the latter’s other products created to treat lung and other cancers using the LADD technology platform. As a result the Phase 1b trial will be conducted by Janssen.

Nivolumab is a human anti-programmed cell death protein 1 (anti-PD-1) that acts as a checkpoint inhibitor by blocking the signal that would prevent activated T cells from attacking the cancer. It was created by Bristol-Myers Squibb and was secured by Janssen following a 2016 clinical collaboration.

Aduro chairman, president and chief executive officer Stephen T Isaacs said: “Based on single agent data from a Phase 1 dose-escalation study in patients with advanced-stage relapsed or refractory non-small cell lung presented at the 2017 International Association for the Study of Lung Cancer’s World Conference, Janssen made the decision to advance ADU-214 in combination with an anti-PD-1 checkpoint inhibitor.

“The initial data demonstrated that five out of nine patients treated with single agent ADU-214 achieved a best response of stable disease, with one patient having received 25 cycles of treatment at the time of data cut off.”

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“The clinical data was supported by biomarker data demonstrating innate immune activation with transient cytokine increases in all patients, as well as induction of mesothelin-specific T cell immunity in a subset of patients, and we are pleased with Janssen’s progress for this program.”