View all newsletters
Receive our newsletter - data, insights and analysis delivered to you
  1. News
March 9, 2021

AIM ImmunoTech initiates dosing in intranasal Covid-19 drug study

AIM ImmunoTech has dosed the first healthy participants in a Phase I clinical study of its Ampligen drug as a potential intranasal prophylaxis or early-stage treatment for Covid-19 and other respiratory viral diseases.

AIM ImmunoTech has dosed the first healthy participants in a Phase I clinical study of its Ampligen drug as a potential intranasal prophylaxis or early-stage treatment for Covid-19 and other respiratory viral diseases.

The clinical study, titled ‘A Phase I, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Activity of Repeated Intranasal Administration of Ampligen (Poly I:Poly C12U) in Healthy Subjects’, is being conducted by the Centre for Human Drug Research (CHDR) institute in the Netherlands.

The study intends to enrol a total of 40 healthy participants with eight each in four Ampligen treatment arms and a placebo arm.

Funded by AIM ImmunoTech, it is designed to evaluate the safety, tolerability, and biological activity of a repeated administration of intranasal Ampligen.

Participants will be given intranasal dosing every other day for a total of 13 days and seven doses.

According to a previous in vitro modelling at The Institute for Antiviral Research at Utah State University, Ampligen demonstrated to lower SARS-CoV-2 infectious viral yields by 90% at clinically achievable intranasal Ampligen dosage levels.

AIM ImmunoTech CEO Thomas Equels said: “We greatly appreciate the tremendous efforts of the entire team at CHDR to help us initiate our Phase 1 study of Ampligen as a potential intranasal therapy.

“Our objective is to expedite the development of Ampligen as potential prophylaxis or treatment for Covid-19.

“Prior results of in vitro modelling were promising, and we are highly encouraged by the potential of an intranasal prophylactic approach using Ampligen to prevent infection and spread of Covid-19.”

Last month, AIM received approval from the required Ethics Committee in the Netherlands to initiate the Phase I clinical study of Ampligen as an intranasal therapy.

Related Companies

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. A weekly roundup of the latest news and analysis, sent every Friday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU

Thank you for subscribing to Pharmaceutical Technology