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December 8, 2017

bluebird bio and TC BioPharm to develop new cancer immunotherapies

US-based gene therapies company bluebird bio has entered a strategic collaboration and licence agreement with Scottish immunotherapy firm TC BioPharm to develop new cancer immunotherapy candidates.

US-based gene therapies company bluebird bio has entered a strategic collaboration and licence agreement with Scottish immunotherapy firm TC BioPharm to develop new cancer immunotherapy candidates.

The firms will focus on the discovery of next-generation liquid and solid tumour therapeutics based on gamma delta CAR T-cells.

In addition to TC BioPharm’s CAR-engineered gamma delta T-cell programme, the firms plan to advance various hematologic and solid tumour targets into clinical trials.

TC BioPharm chief business officer Artin Moussavi said: “We believe our gamma delta T-cell platform has broad therapeutic potential.

“The collaboration with bluebird bio, a leader in cell and gene therapy, recognises the enormous potential of ImmuniCAR to deliver life-changing medicines.”

“The collaboration with bluebird bio, a leader in cell and gene therapy, recognises the enormous potential of ImmuniCAR to deliver life-changing medicines.”

TC BioPharm will be responsible for the development of all identified targets through Phase I/II, while bluebird exercises an exclusive option for their clinical development and commercialisation.

bluebird bio corporate development and strategy senior vice-president Joanne Smith-Farrell said: “bluebird bio is leveraging its industry-leading toolbox of advanced cell and gene therapy technologies to accelerate immuno-oncology targets from concept to clinic.”

According to bluebird, the deal is set to support its expanding immuno-oncology development programme of CAR T and T-Cell Receptor products that utilise the firm’s expertise on translational research and deep vector technology.

The agreement entails $16m upfront and subsequent potential research and development (R&D), as well as commercial milestone payments.

With operations in UK and Japan, TC BioPharm forms strategic alliances with pharmaceutical, biotechnology and research institutions to develop advanced cell therapies.

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