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March 11, 2020

CEL-SCI to develop Covid-19 immunotherapy

Biotechnology company CEL-SCI has begun efforts to develop an immunotherapy for the potential treatment of Covid-19 coronavirus infection.


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Biotechnology company CEL-SCI has begun efforts to develop an immunotherapy for the potential treatment of Covid-19 coronavirus infection.

The company will leverage its LEAPS peptide technology, which could enable immunotherapeutic peptides with antiviral, as well as anti-inflammatory effects.

CEL-SCI notes that LEAPS peptides will use conserved regions of coronavirus proteins to induce protective cell-mediated T-cell responses and also decrease viral load.

In addition to acting on the viral infection, these peptides should trigger a protective response.

Previously, the LEAPS peptides were tested against another respiratory virus, called pandemic influenza (H1N1), in studies performed in alliance with the National Institutes for Allergies and Infectious Diseases (NIAID).

Findings in mice models showed protection from morbidity and mortality via activation of T-cell responses instead of an inflammatory response.

CEL-SCI cellular immunology senior vice-president of research Daniel Zimmerman said: “We believe that a LEAPS Covid-19 coronavirus peptide will reduce or arrest the progression of the virus infection and prevent tissue damage from inflammation resulting from lung infection by the virus.

“In short, we believe that we can stimulate the correct immune responses to the virus without producing unwanted inflammatory responses associated with lung tissue damage. That should be particularly important in the older population who is at highest risk of dying from this virus.”

The proposed LEAPS peptides will target antigens in Covid-19’s NP protein and trigger cytolytic T-cell responses, said the company.

CEL-SCI adds that cytolytic T-cell responses target the cellular ‘factories’ infected by the virus within the host and eliminate the source of the infection.

 

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Free Whitepaper
img

What is the impact of China’s Zero-COVID lockdowns on economic activity, consumer goods and the foodservice industry?

While wanting to protect the country from being overwhelmed by Omicron, China’s adherence to a Zero-COVID policy is resulting in a significant economic downturn. COVID outbreaks in Shanghai, Beijing and many other Chinese cities will impact 2022’s economic growth as consumers and businesses experience rolling lockdowns, leading to a slowdown in domestic and international supply chains. China’s Zero-COVID policy is having a demonstrable impact on consumer-facing industries. Access GlobalData’s new whitepaper, China in 2022: the impact of China’s Zero-COVID lockdowns on economic activity, consumer goods and the foodservice industry, to examine the current situation in Shanghai and other cities in China, to better understand the worst-affected industry sectors, foodservice in particular, and to explore potential growth opportunities as China recovers. The white paper covers:
  • Which multinational companies have been affected?
  • What is the effect of lockdowns on foodservice?
  • What is the effect of lockdowns on Chinese ports?
  • Spotlight on Shanghai: what is the situation there?
  • How have Chinese consumers reacted?
  • How might the Chinese government react?
  • What are the potential growth opportunities?
by GlobalData
Enter your details here to receive your free Whitepaper.

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